Functionalized Fluorinated Isoquinolin-1(2H)-ones for Crop Protection and Pharmaceutical Application The substituted isoquinolin-1(2H)-ones are present in many natural products and pharmaceuticals [1]. On the other side, the isoquinolin-1(2H)-ones are applied in Crop Protection as active agents against abiotic stress in plants [2]. abcr GmbH presents the series of functionalized fluorinated isoquinolin-1(2H)-ones. R2 R3 R1 O R4 H N H H 6-(Difluoromethyl)isoquinolin-1(2H)-one 6,8-Difluoroisoquinolin-1(2H)-one O NH F F F O NH AB426537 CAS 2088945-91-7 F AB426541 CAS 1368752-55-9 6-(Trifluoromethoxy)isoquinolin-1(2H)-one 8-Fluoro-6-methoxyisoquinolin-1(2H)-one O F O F NH NH F F O AB426538 CAS 630423-43-7 O AB426542 CAS 630423-43-7 6-(Difluoromethoxy)isoquinolin-1(2H)-one 6-Fluoro-7-methoxyisoquinolin-1(2H)-one O F NH F O AB426539 CAS 630423-41-5 O NH O F AB426543 CAS 905994-27-6 6,7-Difluoroisoquinolin-1(2H)-one 5,6,7-Trifluoroisoquinolin-1(2H)-one O NH AB400779 CAS 444898-79-7 O NH F F F F F References AB426544 CAS 1506182-55-3 2 . 6 1 6 0 . 4 5 5 6 2 4 (1) (a) Matsui, T., et. al. J. Med. Chem. 1992, 35, 3307; (b) Sunderland, P. T, et. al. J. Med. Chem. 2011, 54, 2049; (c) Busby, S. A., et. al. Chem Biol. 2011, 6, 618. (2) Frackenpohl, J., et. al., Patent WO2013004652 A1. Gute Chemie FONHO