Detection of Poly- and Perfluorinated Carboxylic Acids (PFCA) in Water A Fast and Simple Silylation Reaction Powered by Wasser 3.0 Gute Chemie. PFCAs are widely used organic chemical compounds with very high stability and the ability to repel both water an oil. Because of their widespread exposure to humans, bioaccumulation in the environment and observed toxicity in animal models PFCAs are emerging contaminants. To understand the fate of PFCAs in our environment it is absolutely necessary to receive more analytical data. For the detection of PFCAs it is possible to use either Liquid Chromatography (LC) or Gas Chromatography (GC). The advantages of GC/MS are usually lower costs, better resolution, separation of PFCA-isomers and a widely developed spectra library for simple compound identification. Wasser 3.0 solved the challenge of derivatization with a fast and simple silylation reaction at room temperature. H3C O C7F15C OH + HO Si CH3 CH3 rt, H2O, H2SO4 H3C O C7F15C SiO CH3 CH3 + H2O Example: Derivatization of Perfluorooctanoic acid (PFOA) using Triethylsilanol. Applications of abcr derivatization reagents ■ Gas Chromatography (GC) ■ Liquid Chromatography (LC) ■ High Pressure Liquid Chromatography (HPLC) ■ Ultra Pressure Liquid Chromatography (UPLC) Gute Chemie 1 . 8 1 5 0 . 3 5 6 5 0 5