Organofunctional Silanes Aryne Precursors ISO 9001:2008 DIN EN ISO 9001 abcr offers a large variety of ortho-(trimethylsilyl)aryl triflates, including substituted benzyne precursors, polycyclic aryne precursors and bisaryne precursors. OTf TMS CsF MeCN rt O Ar R R2 N R1 R3 CO2R Ar R N O R O R1 CO2R2 . etc Gute Chemie R1 R2 Ts N R1 R2 N N R R O O N N N R CONR2 O Ar O R2 N N R1 NR1 R2 R3 orto-(Trimethylsilyl)aryl triflates: arynes under mild reaction conditions for synthesis The use of arynes in organic synthesis has under- gone a remarkable revival over the past few years. The key to this resurgence is the use of a method for the generation of benzyne and its derivatives under mild reaction conditions. In particular, fluo- ride-induced decomposition of orto-(trimethylsilyl) aryl triflates allows the generation of arynes in high yields, under neutral reaction conditions at mode- rate temperatures. As a result, this method has proved to be extremely useful in the synthesis of natural products, the preparation of large aromatic compounds, or the synthesis of heterocycles. Figure 1. Some examples of structures that can be obtained in one pot from orto-(trimethylsilyl)aryl triflates via benzyne chemistry (in red the new bonds). SSiOFFFOO