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Commercial Organofunctional Silanes for Diagnostics and Separation 01
Gute Chemie. Connects. Your abcr Team.
Gute Chemie. Foreword 1 Gute Chemie. Welcome to abcr. What do you think of when you hear the expression ‚Gute Chemie‘? Does it make you think of top-quality products or people that understand each other really well? Since we set up our company in 1987, we have consistently attempted to combine both. We offer Gute Chemie in the form of more than 400,000 specialty chemicals that we supply to major pharmaceuticals and chemical companies. And we also provide Gute Chemie in terms of our personal service coupled with an extensive network that links our clients, suppliers and partners all around the world. With this brochure, we would like to invite you to experience all the aspects of Gute Chemie. Dr. Jan Schuricht | Managing Director
Commercial Organofunctional Silanes for Diagnostics and Separation Sciences. Organofunctional silanes are widely used commercially for diagnostics and separation science due to their re- markable versatility. They are hybrid molecules that combine the functionality of a reactive organic group and inorganic functionality into a single molecule. This unique property is used as a molecular bridge to make inorganic materials organically compatible. Organofunctional silanes molecules have two reactive centers, one characterized by at least one hydrolytically stable carbonsilicon bond which allows the introduction of non-reactive or reactive organic functionality such as alkyl, aryl, arylalkyl, perfluorophenylalkyl, amino, epoxy, aldehyde, ethylene and anhydride. The other reactive centers of the silicon atom are characterized by hydrolyzable groups, mainly chloro, alkoxy and amine. The hydrolyzable component of organofunc- tional silanes will hydrolyze readily with water to form silanols and allow silicon to covalently bond to inor- ganic surfaces through a siloxane bond. In addition to forming covalent siloxane bonds with inorganic substrates, the hydrophobic nature of the silicon-carbon bond provides improved resistance at the interphase between siloxane bond and substrate to hydrolysis attack under extreme pH conditions. This feature makes stationary phases and the silica support matrix used in liquid chromatography more hydrolytically stable and hence, indreases service life by protecting the silica’s mechanical properties. The organofunctional silanes can be tri-functional, di-functional and mono-functional. Typical molecular structure for a tri-functional silane R X (CH ) n 2 Si R R R can an example be for chloro, dimethylamine or methoxy X can an example be for hydrogen, perfluorphenyl, phenyl, amino, oxy or cyano In order to initiate the hydrolysis reaction of organo- functional alkoxysilanes to subsequently form covalent siloxane bonds, a catalyst is generally required; typically a mild acid or base will be sufficient. The most common catalysts are acetic acid and ammonia. Chlorosilanes and aminosilanes are autocatalytic because the hy- drolyzable groups will generate in situ, hydrochloric acid or amine thus creating a reaction medium with an acid catalyst with pH 0-1 or a base catalyst with pH 12-14. The tri-functional silanes, e.g. trimethoxysilanes, hy- drolyze first to form a silanol group and then condense with surface hydroxyl groups to form a hydrolytically stable covalent bond and also crosslink to form a multi- layer (silsequioxane) coating. This multilayer is formed at the inorganic interphase and can also diffuse into the a porous matrix to create an interpenetrating net- work within the inorganic substrate which, in turn, generates a more hydrolytically stable silica support for liquid chromatography. The di-functional silanes, e.g. dimethothoxysilanes also hydrolyze first to form a silanol group and then condense with surface hy- droxyl groups to form hydrolytically stable covalent bonds. The di-functional silanes can also form poly- meric materials that can adhere to different types of surfaces. Therefore, organo-functional silanes that are di-functional can be used to make bonded phases for liquid chromatography or make siloxane polymers for capillary columns used in gas chromatography. The mono-functional silanes due to their single hydrolyz- able reactive group will form a self-assemble-mono- layer (SAM) on the inorganic substrate thus creating a uniform molecular layer on the inorganic substrate’s surface. This may offer advanta- ges because the film thickness is easily controlled where it is well known that for tri- and di-functional silanes: reproducibly con- trolling the film thickness can be quite challenging. Typically, mono-functional silanes are used to make bonded phases for analytical applications while due to the higher hydrolytic stability, the di- and tri-functional silanes are more commonly used to make bonded phases for sample prep-scale chromatography, solid phase extraction (SPE) and preparative chromatography
Gute Chemie. Commercial Organofunctional Silanes Reagents 2 | 3 for the purification of active pharmaceutical ingredi- ents (API). An important aspect of bonded phases for liquid chromatography is capping (endcapping) of unre- acted silanol groups left on the inorganic surfaces after the bonding phase step. These unreacted hydroxyl groups adversely affect performance and are there- fore capped with a trimethysilyl group. Hydroxyl and free water scavengers like trimethylchlorosilane and hexamethyldisilazane are efficient however a cus- tomized solution of trimethylchlrosilane and hexa- methyldisilazane has a higher reactivity and is more effective than either of the reagents alone. In addition, capping of silanols groups will lead to free flowing particles which may aid in the reproducibility of column pressures of bonded silica packed chromatography columns. Organofunctional silanes with a hydrolyzable dimethylamino group are versatile silylating reagents for capping silanols. Due to its extreme reactivity with hydroxyl groups, dimethylaminotrimethylsilane is a highly effective silanol scavenger. The by-product formed, dimethylamine, can be easily removed during reflux or by applying vacuum. It must be noted that dimethylamino silanes are ex- tremely hydrolytically sensitive, even more reactive than chlorosilanes. They will almost instantaneously react with moisture in the air; water contained in polar solvents, adsorbed on the surfaces of glass bottles and GC vials. When handling these types of products during analysis, the use of inert gases, silanized GC vials, an- hydrous solvents for syringe cleaning and GC column pre-conditioning are highly recommended. In order to facilitate analysis and process handling these products are also offered as a solution in a non-polar solvent. Depending on the analyte, retention time and selec- tivity, there are numerous organofunctional silanes available for gas and liquid chromatography. A station- ary phase is defined by the specific chemical ligands bonded to the silica support which in combination with solvent and pH, control selectivity and retention time of analytes. The mobile phase is defined by the solvent which contains the analytes. The solvent can be gas as in the case of gas chromatography or non-polar solvents for normal phase chromatography (NPC) or polar solvents for reverse-phase chromatography (RPC) and hydrophilic interaction chromatography (HILIC). Gas (GC) and Liquid Chromatography (LC) employ specific modes of separation which are influenced by the polarity of the stationary phase. The most common ligands found in commercial stationary phases are: Alkyl Phases C18 C8 C4 C1 Phenyl Phases Phenyl Phenyl- alkyl Polar embedded Phases Polar Phases Perfluor- phenyl- propyl Cyano Amino Hydroxyl In addition, in the field of biochromatography, whole new classes of ligands are being investigated for the analysis and purification of natural compounds that are biologically active. Selectivity and retention time are being optimized based on the affinity of these natural compounds to different ligands. The particular nature of the analyte will determine the choice of organofunctional silane as well as the way in which it bonds to the supporting silica matrix. Through a close cooperation with you, abcr labs develops the ideal product solutions to fulfill your particular demands. abcr is your reliable innovation partner for specialty chemicals.
Gute Chemie. abcr and abcr labs. abcr GmbH Germany abcr Locations Worldwide
Gute Chemie. abcr and abcr labs 4 | 5 In 2010, abcr GmbH, located in Karlsruhe, Germany, established a new contract manufacturing facility for fine chemicals and specialty materials, abcr labs S.L. in Forcarei, Spain. The 6,000 m2 manufacturing site provides contract services for custom synthesis, prod- uct and process development, scale-up and commer- cialisation. abcr labs operates 24 hours a day, 5 days a week. The flexible manufacturing platform consists of a kilo lab, pilot plant and full-scale commercial production facilities. In addition, R&D and analytical laboratories provide technical support and testing for raw materials and in-process and finished prod- ucts to support manufacturing operations. abcr labs’ bulk products are shipped to abcr’s logistics centre in Karlsruhe, Germany, for final packaging and global distribution. abcr GmbH has been delivering specialty chemicals to renowned pharmaceutical, chemical and material science-oriented companies worldwide since 1987. Via the 2,500 m2 logistic centre in Karlsruhe, Germany, abcr organises product shipping to more than 10,000 individual laboratories worldwide. Competent assis- tance from our chemists and engineers, worldwide sourcing activities, as well as reliable deliveries at fair prices and excellent quality have made abcr the “preferred supplier” of many customers. abcr keeps stock of most of their 50,000 items up to semi-bulk quantities.
Custom synthesis. Gute Chemie paves the way for new products and processes. Lasting relationships abcr builds lasting relationships with customers by collaborating at all stages of product development, from laboratory scale to commercial production, from gram to ton quantities.
Gute Chemie. Custom synthesis 6 | 7 Chemical process equipment Applications abcr labs chemical process equipment makes use of batch, semi-batch, reactive distillations and continu- ous process technology. The portfolio of chemical processes consists of: For more than 30 years, abcr has been supplying specialty chemicals in laboratory-scale and semi-bulk quantities to companies worldwide. These products can be widely used as: › Condensation › Ammonolysis › Alkyllithium reaction › Grignard formation & reaction › Alkoxylation › Catalytic hydrogenation › Amination › Esterification › Transesterification › Halogenation › Hydrolysis › Hydrosilylation › LAH reduction › Lithiation reaction › Ring opening polymerisation › Silylation › Silylating and protecting groups › Adhesion promoters › Reducing agents › Derivatisation › Various reagents for organic synthesis › Reagents for bioactive reactions › Blocking agents › Surface modification › Thinfilm deposition › Optical and conductive coatings › Catalysis › Polymer synthesis › and many more
In-house production. Gute Chemie means trusting in the quality of the products you make. Kilo lab Pilot plant The kilo laboratory facilities manufacture products in the range of 5 to 15 kg; they are equipped with 6 walk-in fume hoods, one bench top fume hood for weighing and two distillation bench tops for fractional distillations. Pilot plant facilities are composed of six processing suites, two of which are equipped with two reactor pairs with working capacities of 160 and 400 litres. The automated reactors are Pfaudler-Pharmaglass® lined; they have azeotropic, flash and fractional distillation capabilities; they operate from full vacuum to 10 bars of pressure and temperature from -20 °C to 220 °C. A third suite is equipped with a continuous thin film eva- porator for purification of heat sensitive materials and low volatility products. The remaining suites are dedicated for special projects and future expansion.
Gute Chemie. In-house production 8 | 9 Commercial plant The full scale commercial plant facilities are equipped with automated reactors that are Pfaudler-Pharmaglass® lined; have azeotropic, flash and fractional distillation capabilities; operate from full vacuum to 10 bars of pressure and temperatures from -20 °C to 220 °C. Both reactors are supported by a 1,000 litre (1.2 m3) corrosion resistant alloy Neutsche Filter/dryer equipped with automatic cake discharge for rapid turnover and has an operating temperature range from -20 °C to 120 °C. The plant has the infrastructure in place for 4 reactors ranging from 2,500 to 8,000 litres.
Safety. Gute Chemie gives you a feeling of security – from procurement to delivery. Safety: As important as the air we breathe Quality with responsability As in the parent company abcr, at abcr labs highest standards of safety are also observed. This equally applies to environment, health and safety regulations. When it comes to quality assurance, abcr accepts no compromises. As is the case at abcr, the modern production facility is climatically supplied by an earth tube which cools the building by up to 7 °C in the summer and warms it accordingly in the winter. The plants on the roof serve as a natural buffer for tem- perature peaks. abcr has strict standards of quality and is committed to complying with all the environmental, health and safety regulations. Clients are welcome to audit the quality systems that are critical to our success.
Gute Chemie. Safety 10 | 11 Your professional partner for products and services › Custom synthesis for complex multi-step or air-sensitive reactions › Specialty chemicals outsourcing of small or medium- sized products › Tailor-made solutions according to customer needs › Transfer and up-scaling of new processes from laboratory to commercial scale › Silanes and specialty silicones › Metalorganic compounds › Organic intermediates › Organo-Silanes & Silicones
Flexible quantities. Gute Chemie is when you can order any different quantity from the same company.
Gute Chemie. Flexible quantities 12 | 13 Glass bottles Barrels Narrow neck bottle (brown) 5 - 2 500 ml Combination barrels Wide neck bottle (brown) 25 - 2 500 ml Steel barrels inside cover Septum bottle (brown) 50 - 1 000 ml Stainless steel barrels Lab glass bottle with scale (white) 100 - 2 500 ml Plastic barrels (incl. lid & clamping ring) Plastic bottles Aseptic Pharma Containers 6 - 216 l 6 - 220 l 30 - 220 l 30 - 220 l Narrow neck bottle (PFA) (off-white) Narrow neck bottle (PE) (off-white) 60 - 125 ml 60 - 125 ml Wide neck bottle (PE) (off-white) 250 - 2 500 ml Nalgene narrow neck bottle (HDPE) 15 - 1 000 ml Type series C (for aseptic application) 300 ml - 12 l Type series C M (with magnetic stirrer) 600 ml - 12 l Type series CD (M) (with double jacket and optional magnetic stirrer) 1,4 - 12 l Stainless steel bottles GL45 Stainless steel bottles with PE cap 250 - 3 000 ml Stainless steel bottles with Stainless steel cap 100 - 1 000 ml Cylinders Steel cylinders 25 - 2 400 ml Stainless steel cylinders 50 ml - 3.78 l (1 Gallone) Stainless steel bubblers Stainless steel bubblers with standard valve Stainless steel bubblers with cross-purge valve Plastic canisters Plastic canisters 1.5 l - 33 l 150 ml - 1 000 l 5 - 20 l
SiCl
Gute Chemie. Products 15 Diagnostics and Separation. Table of contents. C18, n-Octadecylsilanes C8, n-Octylsilanes C4, n-Butylsilanes C1, Trimethylsilylating Agents for Silanol Capping Arylsilanes Arylalkylsilanes Fluoroarylsilanes Cyano Functional Silanes Amino Functional Silanes Epoxy Functional Alkylsilanes Acetoxy and Aldehyde Functional Alkylsilanes Carboxylic Acid Functional Alkylsilanes Functional Alkylsilanes Polar Embedded Silanes 17 18 19 20 20 21 22 23 24 25 26 26 27 28
Gute Chemie. C18, n-Octadecylsilanes 17 C18, n-Octadecylsilanes AB252576 n-Octadecyldiisobutylchlorosilane; 97% 162578-86-1 Si Cl AB252577 n-Octadecyldiisobutyl(dimethylamino)silane; 95% 151613-23-9 Si N AB336026 n-Octadecyldiisobutyl(dimethylamino)silane; 151613-23-9 25% in toluene Si N AB111257 n-Octadecyldimethylchlorosilane; 97% 18643-08-8 (5-10% C18 isomers) Cl Si AB128282 n-Octadecyldimethylchlorosilane; 70% in toluene 18643-08-8 Cl Si AB129205 n-Octadecyldimethyl(dimethylamino)silane; 76328-77-3 contains 5-10% C18 isomers N Si AB111258 Octadecyldimethylmethoxysilane; 95% 71808-65-6 O Si AB111265 Octadecylmethyldichlorosilane; 97% 5157-75-5 Cl Cl Si AB289989 Octadecylmethyldichlorosilane, 70% in toluene 5157-75-5 Cl Cl Si AB153212 n-Octadecylmethyldimethoxysilane; 70851-50-2 contains 5-10% C18 isomers O Si O abcr GmbH ▪ Phone +49 721 95061 - 0 ▪ Fax +49 721 95061 - 80 ▪ info@abcr.com ▪ www.abcr.com
18 AB108930 n-Octadecyltrichlorosilane; 95%, 112-04-9 cont. 5-10% branched isomers Cl Cl Si Cl AB334057 n-Octadecyltrichlorosilane; 70% in toluene 112-04-9 Cl Cl Si Cl AB336056 n-Octadecyltrimethoxysilane; 97% 3069-42-9 O O Si O C8, n-Octylsilanes AB111284 n-Octyldiisopropylchlorosilane; 90% 117559-37-2 AB111286 n-Octyldimethyl(dimethylamino)silane; 95% 110348-62-4 AB336028 n-Octyldimethyl(dimethylamino)silane; 110348-62-4 25% in toluene AB111285 n-Octyldimethylchlorosilane; 97% 18162-84-0 AB131060 n-Octyldimethylmethoxysilane; 95% 93804-29-6 AB111287 n-Octylmethyldichlorosilane; 97% 14799-93-0 AB134462 n-Octylmethyldimethoxysilane; 95% 85712-15-8 Gute Chemie Si Cl N Si N Si Cl Si O Si Cl Cl Si O Si O
Gute Chemie. C8, n-Octylsilanes | C4, n-Butylsilane 19 AB111290 n-Octyltrichlorosilane; 97% 5283-66-9 AB129289 n-Octyltrimethoxysilane; 97% 3069-40-7 Cl Cl Si Cl O O Si O C4, n-Butylsilanes AB110913 n-Butyldimethylchlorosilane; 97% 1000-50-6 AB129275 n-Butyldimethyl(dimethylamino)silane; 95% 181231-67-4 AB336029 n-Butyldimethyl(dimethylamino)silane; 25% in toluene 181231-67-4 AB252498 n-Butyldimethylmethoxysilane 64712-50-1 AB110923 n-Butylmethyldichlorosilane; 97% 18147-23-4 AB334058 n-Butylmethyldimethoxysilane; 97% 18294-08-1 AB110926 n-Butyltrichlorosilane; 97% 7521-80-4 AB110928 n-Butyltrimethoxysilane; 97% 1067-57-8 Cl Si N Si N Si O Si Cl Cl Si Cl Cl Si Cl O O Si O O Si O abcr GmbH ▪ Phone +49 721 95061 - 0 ▪ Fax +49 721 95061 - 80 ▪ info@abcr.com ▪ www.abcr.com
20 C1, Trimethylsilylating Agents for Silanol Capping AB357480 (N,N-Dimethylamino)trimethylsilane; 98% 2083-91-2 AB336030 (N,N-Dimethylamino)trimethylsilane; 25% in toluene 2083-91-2 AB119949 N-(Trimethylsilyl)imidazole; 97% 18156-74-6 AB111495 Trimethylchlorosilane; 99% 75-77-4 AB210603 Methoxytrimethylsilane; 97% 1825-61-2 AB111175 Hexamethyldisilazane; 99.5% 999-97-3 AB334055 TMS silylating solution (hexamethyldisilazane/ 999-97-3 chlorotrimethylsilane) Arylsilanes AB111322 Phenyldimethylchlorosilane; 97% 768-33-2 AB111339 Phenyltrichlorosilane; 97% 98-13-5 AB111342 Phenyltrimethoxysilane; 97% 2996-92-1 Si N Si N NSi N Cl Si Si O Si Si N H Cl Si Cl Cl Si Cl O O Si O AB110855 1,4-Bis(dimethylsilyl)benzene; 97% 2488-01-9 H Si Si H Gute Chemie
Gute Chemie. C1, Trimethylsilylating Agents for Silanol Capping | Arylsilanes | Arylalkylsilanes 21 AB110858 1,4-Bis(hydroxydimethylsilyl)benzene; 95% 2754-32-7 AB304369 4-Biphenyldimethylchlorosilane; 95% 41081-31-6 HO Si Si OH Si Cl Arylalkylsilanes AB252611 6-Phenylhexyldimethylchlorosilane; 97% 97451-53-1 AB334056 6-Phenylhexyldimethyl(dimethylamino)silane; 95% 1223044-18-5 AB336032 6-Phenylhexyldimethyl(dimethylamino)silane; 25% in toluene 1223044-18-5 AB334062 6-Phenylhexyldimethylmethoxysilane; 97% 1858242-16-6 AB334060 6-Phenylhexylmethyldichlorosilane; 97% 97451-52-0 AB334061 6-Phenylhexylmethyldimethoxysilane; 97% 1858240-78-4 AB201456 6-Phenylhexyltrichlorosilane; 97% 18035-33-1 AB334063 6-Phenylhexyltrimethoxysilane; 97% 1640036-44-7 AB336053 3-Phenylpropyldimethyl(dimethylamino)silane; 95% 1858241-47-0 Si Cl Si N Si N Si O Cl Si Cl O Si O Cl Cl Si Cl O O Si O Si N abcr GmbH ▪ Phone +49 721 95061 - 0 ▪ Fax +49 721 95061 - 80 ▪ info@abcr.com ▪ www.abcr.com
22 AB336031 3-Phenylpropyldimethyl(dimethylamino)silane; 1858241-47-0 25% in toluene AB111335 (3-Phenylpropyl)dimethylchlorosilane; 97% 17146-09-7 AB331574 3-Phenylpropyldimethylmethoxysilane; 97% 52500-10-4 AB129299 (3-Phenylpropyl)methyldichlorosilane; 97% 17776-66-8 AB331582 (3-Phenylpropyl)methyldimethoxysilane; 97% 1233513-31-9 AB252612 (3-Phenylpropyl)trichlorosilane; 97% 13617-40-8 AB334059 (3-Phenylpropyl)trimethoxysilane; 97% 152958-90-2 Si Cl O Si Si N Si Cl Cl O Si O Cl Si Cl Cl O Si O O Fluoroarylsilanes AB129290 Pentafluorophenyldimethylchlorosilane; 95% 20082-71-7 F F AB251701 Pentafluorophenyldimethylsilyldiethylamine 55485-74-0 AB129291 Pentafluorophenylpropyldimethylchlorosilane; 97% 157499-19-9 Gute Chemie Cl Si F F F Si N F F F F F F F F F Si Cl F
Gute Chemie. Fluoroarylsilanes | Cyano Functional Silanes 23 AB134463 Pentafluorophenylpropylmethyldichlorosilane; 97% 1220126-66-8 AB334064 (Pentafluorophenylpropyl)methyldimethoxysilane; 97% 1858256-21-9 AB126774 Pentafluorophenylpropyltrichlorosilane; 97% 78900-02-4 AB126792 Pentafluorophenylpropyltrimethoxysilane; 97% 303191-26-6 AB134664 Pentafluorophenyltriethoxysilane; 97% 20083-34-5 Cyano Functional Silanes AB252516 (3-Cyanopropyl)dimethyl(dimethylamino)silane 111873-32-6 AB336033 (3-Cyanopropyl)dimethyl(dimethylamino)silane; 25% in toluene 111873-32-6 AB110994 (3-Cyanopropyl)dimethylchlorosilane; 97% 18156-15-5 AB336080 3-Cyanopropyldimethylmethoxysilane; 97% 143203-47-8 AB110995 3-Cyanopropylmethyldichlorosilane; 97% 1190-16-5 F F F F O Si O F F F F F F F F Cl Si Cl F F F F Cl Si Cl Cl O Si O O F F F F O O Si O F F F F F N Si N Si Cl Si O Si Cl Cl Si N N N N N abcr GmbH ▪ Phone +49 721 95061 - 0 ▪ Fax +49 721 95061 - 80 ▪ info@abcr.com ▪ www.abcr.com
24 AB109879 3-Cyanopropylmethyldimethoxysilane; 97% 153723-40-1 AB129111 (3-Cyanopropyl)phenyldichlorosilane; 97% 1078-96-2 AB153315 3-Cyanopropylphenyldimethoxysilane; 95% 204760-82-7 AB110996 (3-Cyanopropyl)trichlorosilane; 97% 1071-27-8 AB128523 (3-Cyanopropyl)trimethoxysilane; 97% 55453-24-2 O Si O Cl Si Cl O Si O Cl Cl Si Cl O O Si O N N N N N AB134446 11-Cyanoundecyltrichlorosilane; 95% 724460-16-6 AB129096 11-Cyanoundecyltrimethoxysilane; 97% 253788-37-3 Cl Cl Si Cl O O Si O N N Amino Functional Silanes AB336100 4-Aminophenyltrimethoxysilane; 95% 33976-43-1 AB110423 3-Aminopropyldimethylethoxysilane; 97% 18306-79-1 AB222531 3-Aminopropylmethyldimethoxysilane; 95% 3663-44-3 AB336097 3-Aminopropyltrimethoxysilane; 97% 13822-56-5 Gute Chemie O O Si O NH2 O Si NH2 O Si O NH2 H2N O O Si O
Gute Chemie. Amino Functional Silanes | Epoxy Functional Alkylsilanes 25 AB153236 11-Aminoundecyltriethoxysilane; 95% 116821-45-5 O O Si O NH2 AB252529 (3-N,N-Dimethylaminopropyl)methyldimethoxysilane; 97% 67353-42-8 AB336017 (3-N,N-Dimethylaminopropyl)triethoxysilane; 97% 43108-00-5 AB110559 (3-N,N-Dimethylaminopropyl)trimethoxysilane; 97% 2530-86-1 AB111305 (N-Phenylaminopropyl)trimethoxysilane; 95% 3068-76-6 Epoxy Functional Alkylsilanes AB129137 5,6-Epoxyhexyltriethoxysilane; 97% 86138-01-4 AB111148 (3-Glycidoxypropyl)dimethylethoxysilane; 97% 17963-04-1 AB111152 (3-Glycidoxypropyl)trimethoxysilane; 98% 2530-83-8 O Si O N O O Si O O O Si O N N O O Si O H N O O O Si O O O Si O O Si O O O O abcr GmbH ▪ Phone +49 721 95061 - 0 ▪ Fax +49 721 95061 - 80 ▪ info@abcr.com ▪ www.abcr.com
26 Acetoxy and Aldehyde Functional Alkylsilanes AB110781 Acetoxyethyldimethylchlorosilane; 97% 18306-45-1 AB110783 Acetoxyethyltrichlorosilane; 97% 18204-80-3 Cl Si O O Cl Cl Si Cl O O AB252438 2-(4-Acetoxyphenyl)ethyltrichlorosilane; 97% 627882-90-0 O O AB128800 3-(Triethoxysilyl)propylsuccinic anhydride; 93642-68-3 tech. 60-70% AB152514 11-(Triethoxysilyl)undecanal; 90% 116047-42-8 Carboxylic Acid Functional Alkylsilanes AB391080 5-Triethoxysilylpentanoic acid; tech. 1137665-94-1 AB391081 6-Triethoxysilylhexanoic acid; 95% 145045-54-1 AB391082 7-Triethoxysilylheptanoic acid; 95% 1858242-65-5 Cl Si Cl Cl O Si O O O O Si O O O Si O O O O O O OH O O Si O O OH O O Si O OH O Gute Chemie
Gute Chemie. Acetoxy and Aldehyde & Carboxylic Acid Functional Alkylsilanes | Functional Alkylsilanes 27 O OH OH O O OH OH O AB391083 8-Triethoxysilyloctanoic acid; 95% 1858255-00-1 AB391084 9-Triethoxysilylnonanoic acid; 95% 1858251-01-0 AB391085 10-Triethoxysilyldecanoic acid; 95% 1643983-72-5 AB391086 11-Triethoxysilylundecanoic acid; 95% 82784-73-4 Functional Alkylsilanes AB111280 7-Octenyldimethylchlorosilane; 95% 17196-12-2 AB171364 7-Octenyldimethylmethoxysilane; 95% 204775-11-1 AB111282 7-Octenyltrimethoxysilane; 95% 52217-57-9 AB134479 10-Undecenyltrichlorosilane; 95% 17963-29-0 AB153354 10-Undecenyltrimethoxysilane; 95% (sum of isomers, ca. 90% n-C11) 872575-06-9 O O Si O O O Si O O O Si O O O Si O Cl Si O Si O O Si O Cl Cl Si Cl O O Si O abcr GmbH ▪ Phone +49 721 95061 - 0 ▪ Fax +49 721 95061 - 80 ▪ info@abcr.com ▪ www.abcr.com
28 AB110910 11-Bromoundecyltrichlorosilane; 95% 79769-48-5 AB110911 11-Bromoundecyltrimethoxysilane; 95% 17947-99-8 Cl Cl Si Cl O O Si O Br Br Polar Embedded Silanes AB334066 N-[3-(Dimethoxymethylsilyl)propyl]hexadecanamide; 1858240-83-1 95% O Si O AB334065 N-[3-(Methoxydimethylsilyl)propyl]hexadecanamide; 1240493-11-1 95% O Si AB290843 N-[3-(Trimethoxysilyl)propyl]hexadecanamide; 95% 862822-32-0 O O Si O N H N H H N O O O Gute Chemie
Publishing details abcr GmbH Im Schlehert 10 76187 Karlsruhe Germany Phone +49 721 95061 - 0 Fax +49 721 95061 - 80 info@abcr.com ▪ www.abcr.com Registered office Karlsruhe Managing Director Dr. Jan Schuricht District court AG Mannheim HRB 104793 Tax number 35005/14749 VAT number DE 815518524 DUNS number 320054844 Publisher: abcr GmbH 357177.0912.9-23 © abcr - All rights reserved.
Gute Chemie. Greater diversity, choice and value. Make use of our e-papers to quickly and easily browse through our catalogues and flyers and search for products. All products listed in the e-papers are linked to the respective product detail page within our website where you will find further information. We can also send the catalogues and flyers by mail. Silicon Compounds Life Science Drug Design Fluorinated Compounds Organozinc Reagents Palladium Catalysts Aryne Precursors Freaky Amino Acids Catalysts Ligands Find 400,000 specialty chemicals in our webshop www.abcr.com abcr GmbH Germany +49 721 95061-0 info@abcr.com abcr swiss AG +41 41 7201882 info@abcr-swiss.ch abcr france SAS +33 4 7291 3100 info@abcr-france.fr abcr IRL Ltd. +353 56 7738971 info@abcr-irl.ie abcr UK Ltd. +44 161 8187062 info@abcr-uk.com LLC ABCR CHEMI RUS +7 495 9664181 info@abcr-russia.ru (R,R)-Catalyst (35 mol-%)MnO2 (3 eq.), Li2CO3 (2 eq.)PhCF3, 115 °C, 24 hup to 86% yield) (2 eq.)NNOSO2RHHNNHSO2Rup to 94% yield(S,S)-ligand (8 mol-%)THF, diglyme-20°CRalkylNN)(S,S)-ligand (8 mol-%)R1CF3R1+F3C(S,S)-ligand (8 mol-%THF, diglym-20°alkylCoI2 (10 mol-%)(S,S)-ligand (12 mol-%)THF, -80°CArylMgBrROup to 96% yield)ROArylalkylCo(S,S)-ligand (12 mol-%THF, -80°CROBralkyl+ArylMgBrup to 96% yieldONNOCuTfOOTfNNO(R,R)-Catalyst (35 mol-%)MnO2 (3 eq.), Li2CO3 (2 eq.)PhCF3, 115 °C, 24 hup to 86% yield) (2 eq.)NNOSO2RHHNNHSO2RR2(DME)NiCl2 (5 mol-%)(S,S)-ligand (6 mol-%)TMEDA (1.6 eq.)THF, 0°Cup to 94% yieldR (5 mol-%) (6 mol-%)R1FFNOR2R2ZnClR1+BrFFNOR2R2(DME)NiCl(S,S)-ligandTMEDA (1.6 eq.)THF, 0°Cup to 94% yield(DME)NiCl2 (6 mol-%)(S,S)-ligand (8 mol-%)THF, diglyme-20°CRalkylONNO)(S,S)-ligand (8 mol-%)R1alkylCF3ZnClR1+F3C(DME)NiCl(S,S)-ligand (8 mol-%THF, diglym-20°XalkylCoI2 (10 mol-%)(S,S)-ligand (12 mol-%)THF, -80°CArylMgBrROup to 96% yield)ROArylalkylCo(S,S)-ligand (12 mol-%THF, -80°CROBralkyl+ArylMgBrup to 96% yieldNNO(S,S)-ligandONNOCuTfOOTfNNOCO2RArORArOCONR2OR1R2ArRNNNRONRNNR2R1NNRTsNR1R2R1CO2R2ONR1R2R3NR1R2R3OORetc.OTfTMSCsFCO2RArORArOCONR2OR1R2ArRNNNRONRNNR2R1NNRTsNR1R2R1CO2R2ONR1R2R3NR1R2R3OORetc.MeCNrtLife ScienceNew Chirals for Drug DesignNNNN01Life ScienceNew Chirals for Drug DesignNNNN0101Available in bulk quantities Fluoro Organic Intermediates01Available in bulk quantities Fluoro Organic IntermediatesNew Organozinc Reagents for Organic Synthesis01New Organozinc Reagents for Organic Synthesis01Palladium catalysts for C-C and C-N coupling reactions01Palladium catalysts for C-C and C-N coupling reactions01