Fluoro-02

Welcome to abcr.
The company.
Fluoro Benzodioxine and -dioxanes
Contact.

Gute Chemie. Foreword 1 Gute Chemie. Welcome to abcr. What do you think of when you hear the expression ‚Gute Chemie‘? Does it make you think of top-quality products or people that understand each other really well? Since we set up our company in 1987, we have consistently attempted to combine both. We offer Gute Chemie in the form of more than 400,000 specialty chemicals that we supply to major pharmaceuticals and chemical companies. And we also provide Gute Chemie in terms of our personal service coupled with an extensive network that links our clients, suppliers and partners all around the world. With this brochure, we would like to invite you to experience all the aspects of Gute Chemie. Dr. Jan Schuricht | Managing Director

Gute Chemie. abcr 2 | 3 With abcr, you have access to over 400,000 products from the organic, organometallic and inorganic specialty chemical areas. You can order all of these materials conveniently via our webshop and we keep a large portion of them on stock for you in our logistics centre. Should your desired product not be among them, we will seek out a suitable manufacturer in our international network, or synthesise it in our own laboratories. Working with all sectors Specialisation as standard: our key business fields Pharmaceutical and chemical companies, research labs and universities: our range of products is as diverse as the customers that use them. Applications for abcr’s specialty chemicals include synthesis and catalysis in the life sciences, medicinal chemistry and surface technology areas. We are constantly updating and expanding our product range in line with the progress in research and development. › R&D services: custom synthesis, research projects and abcr product line from our laboratory - Made in Germany › Production: research, process development, scale-up in multi tons scale, syntheses and contract manufacturing from our production facilities - Made in Europe › Bulk business: procurement, scale up and sales of raw materials for your production › Catalogue business: procurement and sales of specialty chemicals, more than 400.000 products easily found in our webshop › Small quantity supply: sample and small quantity sales for products of well-known partners › Services: central warehouse and logistics certified for storage of hazardous materials, daily filling and decanting from grams to tons In our catalogue business you will find following product portfolio: Silanes & Silicones Fluoro Compounds Organometallics Ionic Liquids Monomers & Polymers Biochemistry Reagents Boronic Acids & Esters Specialty Gases Amino Acids Phosphines Catalysts & Ligands Nanomaterials Ceramic Powders Precious Metal Compounds High Purity Metals Rare Earth Compounds Building Blocks Deuterated Compounds Sol-gel Precursor CVD Precursor Solvents

In-house production. Gute Chemie means trusting in the quality of the products you make. abcr R&D Services Germany develops and supply new products and intermediates for material science, pharmaceutical and crop protection, life-science industries as well as for research and education applications. With R&D Service we focus on novel unknown compounds in organic chemistry with special strength in fluorinated chemistry and offer a catalogue with more than 500 unique products, custom synthesis services or contracted synthesis as well as contract research projects. Our production scale in multi-step synthesis varies and can be scaled up in our production facility “abcr labs”. Applications of fluorinated building blocks › Building blocks applied in construction of fluorinated peptide and protein structures Chemicals process development and performed reactions scale: multi-step multi-gram synthesis with scale-up possibility › Building blocks for medicinal chemistry and crop › Fluorination with FAR-reagents, SF4, DAST, protection industry › Building blocks for the synthesis of novel stable carbenes, radical species, super-acids, weakly coordinating anions, and other materials for both applied and basic research › High-pure optically active fluorine containing compounds › Fluorinated organic materials for material science esp. OLED and LC applications › Catalysis › Ophthalmology phenylsulfurtrifluoride and tetrabutylammonium dihydrogen trifluoride › Phase-transfer catalysis for fluorination in numerous organic reactions › Solid-liquid phase transfer Halex fluorination › Trifluoromethoxylation › Pentafluoroethoxylation › Fluoromethylation › Difluoromethylation › Trifluoromethylation › Polyfluoroalkylation › Electrofluorination

Gute Chemie. In-house production 4 | 5 abcr labs in Galicia, Spain is our contract manufacturing facility for fine chemicals and specialty materials, established in 2010. The 6,000 m2 manufacturing site provides contract services for custom synthesis, product and process development, scale-up and commercialisation. abcr labs operates 24 hours a day, 5 days a week. The flexible manufacturing platform consists of a kilo lab, a pilot plant and full-scale commercial production facilities. In addition, R&D and analytical laboratories provide technical support and testing for raw materials and in-process and finished products to support manufacturing operations. abcr labs’ bulk products are shipped to abcr’s logistics centre in Karlsruhe, Germany, for final packaging and global distribution. Chemical process equipment Applications abcr labs chemical process equipment makes use of batch, semi-batch, reactive distillations and continu- ous process technology. The portfolio of chemical processes consists of: For more than 30 years, abcr has been supplying specialty chemicals in laboratory-scale and semi-bulk quantities to companies worldwide. These products can be widely used as: › Condensation › Ammonolysis › Alkyllithium reaction › Grignard formation & reaction › Alkoxylation › Catalytic hydrogenation › Amination › Esterification › Transesterification › Halogenation › Hydrolysis › Hydrosilylation › LAH reduction › Lithiation reaction › Ring opening polymerisation › Silylation › Silylating and protecting groups › Adhesion promoters › Reducing agents › Derivatisation › Various reagents for organic synthesis › Reagents for bioactive reactions › Blocking agents › Surface modification › Thinfilm deposition › Optical and conductive coatings › Catalysis › Polymer synthesis › and many more

Gute Chemie. Flexible quantities 6 | 7 Glass bottles Barrels Narrow neck bottle (brown) 5 - 2 500 ml Combination barrels Wide neck bottle (brown) 25 - 2 500 ml Steel barrels inside cover Septum bottle (brown) 50 - 1 000 ml Stainless steel barrels Lab glass bottle with scale (white) 100 - 2 500 ml Plastic barrels (incl. lid & clamping ring) Plastic bottles Aseptic Pharma Containers 6 - 216 l 6 - 220 l 30 - 220 l 30 - 220 l Narrow neck bottle (PFA) (off-white) Narrow neck bottle (PE) (off-white) 60 - 125 ml 60 - 125 ml Wide neck bottle (PE) (off-white) 250 - 2 500 ml Nalgene narrow neck bottle (HDPE) 15 - 1 000 ml Type series C (for aseptic application) 300 ml - 12 l Type series C M (with magnetic stirrer) 600 ml - 12 l Type series CD (M) (with double jacket and optional magnetic stirrer) 1,4 - 12 l Stainless steel bottles GL45 Stainless steel bottles with PE cap 250 - 3 000 ml Stainless steel bottles with Stainless steel cap 100 - 1 000 ml Cylinders Steel cylinders 25 - 2 400 ml Stainless steel cylinders 50 ml - 3.78 l (1 Gallone) Stainless steel bubblers Stainless steel bubblers with standard valve Stainless steel bubblers with cross-purge valve Plastic canisters Plastic canisters 1.5 l - 33 l 150 ml - 1 000 l 5 - 20 l

Gute Chemie. Fluoro Benzodioxine and -dioxanes 9 AB274969 3-Chloro-2,2,3-triﬂuoro-2,3-dihydro-7-nitro-1,4- benzodioxin-6-amine 97966-64-8 AB275062 2,2,3,3-Tetraﬂuoro-1,4-benzodioxene-6-carbaldehyde 159276-63-8 AB275092 2,2,3-Triﬂuoro-2,3-dihydro-7-methyl-1,4-benzodioxin; 95% 159276-64-9 AB275157 3-Chloro-2,2,3-triﬂuoro-2,3-dihydro-1,4-benzodioxin- 6-amine; 95% 75289-41-7 AB275785 6-(N-Methylphthalimido)-2,2,3-triﬂuoro-1,4-benzo- dioxane 1357626-62-0 AB275862 6-Chloro-2,2,3-triﬂuoro-1,4-benzodioxane; 80% 1357626-60-8 AB276069 7-Nitro-2,3-dihydro-1,4-benzodioxin-6-amine 62140-78-7 AB276071 2,3-Dichloro-2,3-diﬂuoro-1,4-benzodioxane; 97% 173193-88-9 AB276103 7-Methyl-2,2,3-triﬂuoro-2,3-dihydro-1,4-benzodioxin- 6-amine; 94% 1357624-96-4 H2N O2N F F F F F F F F F Cl F O O O O O O O N O O O F F F O2N H2N Cl Cl F F F O O F F O O AB276123 2,2-Diﬂuoro-3,3-dimethyl-6,8-dinitro-2,3-dihydro- 1,4-benzodioxin; 90% 1357624-37-3 NO2 AB276188 2,2,3-Triﬂuoro-6-aminomethyl-1,4-benzodioxane 1357624-40-8 AB276416 2-Chloro-2,3,3-triﬂuoro-2,3-dihydro- 6-(trichloromethyl)-1,4-benzodioxin; 98% 180091-34-3 O2N H2N Cl Cl Cl O O Cl F F F O NH2 O F F O F Cl O O NH2 F F O O O F F O F O O F F Cl F abcr GmbH ▪ Phone +49 721 95061 - 0 ▪ Fax +49 721 95061 - 80 ▪ info@abcr.com ▪ www.abcr.com

10 AB276418 2,2-Diﬂuoro-2,3-dihydro-3-phenyl-1,4-benzodioxin; 95% 103467-06-7 F F O AB276431 6-Amino-2,2,3-trichloro-3-ﬂuoro-2,3-dihydro-1,4- benzodioxin 1357623-96-1 AB276445 2,2-Diﬂuoro-2,3-dihydro-3-methyl-1,4-benzodioxin; 95% 103467-05-6 AB276446 2,3,3-Triﬂuoro-2,3-dihydro-6-dichloromethyl-1,4- benzodioxin; 96% 1357626-54-0 AB276543 2,3-Dichloro-2,3-diﬂuoro-6-cyano-2,3-dihydro-1,4- benzodioxin; 97% 1357626-02-8 AB276545 3-Chloro-2,2,3-triﬂuoro-1,4-benzodioxane-6-carbonitrile; 97% 1357624-17-9 AB276656 2-Chloro-2,3,3-triﬂuoro-2,3-dihydro- 1,4-benzodioxin- 6-carbonyl chloride; 98% 180418-47-7 O O O F Cl Cl Cl O O F F Cl O O O O Cl F F F F Cl Cl Cl F O Cl NH2 F O O F F N N O O F F Cl F AB277543 2,2,4,4-Tetraﬂuoro-1,3-benzodioxene 25857-79-8 F F AB277956 2,2,3-Triﬂuoro-4-methoxy-5,7-dinitrobenzodioxane 1858257-15-4 AB284469 2,3-Dihydro-benzo[1,4]dioxine-2-carboxylic acid ethyl ester; 95% 4739-94-0 O F O F O2N O NO2 O O F F F O O O O AB278150 6-Nitro-1,3-benzodioxan 6963-03-7 O2N O O Gute Chemie

Gute Chemie. Fluoro Benzodioxine and -dioxanes 11 AB278210 2,2,3-Triﬂuoro-6-isocyanato-1,4-benzodioxane; 92% 75289-34-8 N O F AB278546 2,3,3,7-Tetraﬂuoro-2,3-dihydro-1,4-benzodioxin- 6-amine; 90% 120934-08-9 AB278550 trans-2,3-Dichloro-2,3-dihydro-5-methyl-1,4-benzo- dioxin 111494-99-6 AB278703 2,4,4-Triﬂuoro-6-nitro-2-(triﬂuoromethyl)-1,3-benzo- dioxan; 95% 25854-53-9 AB278897 2,3-Dichloro-2,3-dihydro-1,4-benzodioxin; 98% 152946-83-3 AB278950 5-(Dichloromethyl)-2,2,3-triﬂuoro-1,4-benzodioxane 1435806-56-6 AB278969 2,2,3,3-Tetraﬂuoro-2,3-dihydro-1,4-benzodioxin- 5-carboxylic acid; 90% 398156-39-3 AB279025 2-(Fluoromethyl)-2,3-dihydro-1,4-benzodioxin 106533-32-8 AB279326 2,3-Dihydro-2,3-dioxo-1,4-benzodioxin-6-carboxylic acid methyl ester 97005-07-7 AB279482 6-Bromo- 2,3-dichloro-2,3-diﬂuoro-1,4-benzodioxane; 97% 1435807-07-0 AB279514 2,4,4-Triﬂuoro-2-(triﬂuoromethyl)-4H-1,3-benzodioxin- 6-amine; 98% 872707-38-5 C O F F F O O F O F NH2 F O Cl O Cl F F F F3C O O NO2 Cl O Cl O O F F O Cl F Cl O F F F O O OH F O O F O O F F Cl Cl O O O O O O Br F F F F3C O O NH2 abcr GmbH ▪ Phone +49 721 95061 - 0 ▪ Fax +49 721 95061 - 80 ▪ info@abcr.com ▪ www.abcr.com

12 AB279528 2,2,3-Triﬂuoro-2,3-dihydro-1,4-benzodioxin-6-carbo- xylic acid 136593-46-9 AB279581 2,2,3,3-Tetrachloro-5,6,7,8-tetraﬂuoro-2,3-dihydro- 1,4-benzodioxin 664326-96-9 AB279592 2,2,3,3-Tetrabromo-1,4-benzodioxane; 97% 1435806-83-9 AB129171 2,2,4,4-Tetraﬂuoro-6-isocyanato-1,3-benzodioxene 26030-46-6 AB279793 2,2-Diﬂuoro-3,3-dimethyl-6-bromo-1,4-benzodioxane; 97% 1435807-04-7 AB279818 2-Chloro-2,3,3-triﬂuoro-2,3-dihydro-1,4-benzodioxin; 97% 75289-44-0 O F F O F O O Cl Cl Cl Cl N C O Br OH O F F F F Br Br Br Br O O F F O F O F O O F F F F Cl F O O Gute Chemie

Gute Chemie. Greater diversity, choice and value. Make use of our e-papers to quickly and easily browse through our catalogues and flyers and search for products. All products listed in the e-papers are linked to the respective product detail page within our website where you will find further information. We can also send the catalogues and flyers by mail. Fluorinated Compounds Life Science Drug Design Silicon Compounds Organozinc Reagents Palladium Catalysts Fluoro Triflates Freaky Amino Acids Catalysts Ligands Find 400,000 specialty chemicals in our webshop www.abcr.com abcr GmbH Germany +49 721 95061-0 info@abcr.com abcr swiss AG +41 41 7201882 info@abcr-swiss.ch abcr france SAS +33 4 7291 3100 info@abcr-france.fr abcr IRL Ltd. +353 56 7738971 info@abcr-irl.ie abcr UK Ltd. +44 161 8187062 info@abcr-uk.com LLC ABCR CHEMI RUS +7 495 9664181 info@abcr-russia.ru (R,R)-Catalyst (35 mol-%)MnO2 (3 eq.), Li2CO3 (2 eq.)PhCF3, 115 °C, 24 hup to 86% yield) (2 eq.)NNOSO2RHHNNHSO2Rup to 94% yield(S,S)-ligand (8 mol-%)THF, diglyme-20°CRalkylNN)(S,S)-ligand (8 mol-%)R1CF3R1+F3C(S,S)-ligand (8 mol-%THF, diglym-20°alkylCoI2 (10 mol-%)(S,S)-ligand (12 mol-%)THF, -80°CArylMgBrROup to 96% yield)ROArylalkylCo(S,S)-ligand (12 mol-%THF, -80°CROBralkyl+ArylMgBrup to 96% yieldONNOCuTfOOTfNNO(R,R)-Catalyst (35 mol-%)MnO2 (3 eq.), Li2CO3 (2 eq.)PhCF3, 115 °C, 24 hup to 86% yield) (2 eq.)NNOSO2RHHNNHSO2RR2(DME)NiCl2 (5 mol-%)(S,S)-ligand (6 mol-%)TMEDA (1.6 eq.)THF, 0°Cup to 94% yieldR (5 mol-%) (6 mol-%)R1FFNOR2R2ZnClR1+BrFFNOR2R2(DME)NiCl(S,S)-ligandTMEDA (1.6 eq.)THF, 0°Cup to 94% yield(DME)NiCl2 (6 mol-%)(S,S)-ligand (8 mol-%)THF, diglyme-20°CRalkylONNO)(S,S)-ligand (8 mol-%)R1alkylCF3ZnClR1+F3C(DME)NiCl(S,S)-ligand (8 mol-%THF, diglym-20°XalkylCoI2 (10 mol-%)(S,S)-ligand (12 mol-%)THF, -80°CArylMgBrROup to 96% yield)ROArylalkylCo(S,S)-ligand (12 mol-%THF, -80°CROBralkyl+ArylMgBrup to 96% yieldNNO(S,S)-ligandONNOCuTfOOTfNNOLife ScienceNew Chirals for Drug DesignNNNN01Life ScienceNew Chirals for Drug DesignNNNN01New Organozinc Reagents for Organic Synthesis01New Organozinc Reagents for Organic Synthesis01Palladium catalysts for C-C and C-N coupling reactions01Palladium catalysts for C-C and C-N coupling reactions01Commercial Organofunctional Silanes for Diagnostics and Separation01Commercial Organofunctional Silanes for Diagnostics and Separation0101Available in bulk quantities Fluoro Organic Intermediates01Available in bulk quantities Fluoro Organic Intermediates

Welcome to abcr.

The company.

Fluoro Benzodioxine and -dioxanes

Contact.